Experts discovered in olive oil a potent inhibitor for multiple myeloma.
A team of scientists of the Hospital Clínico Universitario de Santiago, discovered the anti-tumor potential of 'oleocanthal' as an inhibitor of proliferation of human cells in the case of multiple myeloma. The work, done in collaboration with the Department of chemical at the University of Pennsylvania (USA) will be published in the journal Current Medical Chemistry.
Multiple myeloma (MM) is a plasma cell malignancy that causes devastating bone destruction by activating osteoclasts in the bone marrow milieu. MM is the second of all hematological malignancies. Thus, the search for new pharmacological weapons is under intensive investigation being MM a critically important public health goal.
Recently, it has been demonstrated that macrophage inflammatory protein 1- alpha (MIP-1α) is crucially involved in the development of osteolytic bone lesions in MM. Phenolic components of extra virgin olive oil are reported to have anti tumor activity. However, the underlying mechanisms and specific targets of extra virgin olive oil remain to be elucidated.
In this study, are investigated the effects of a recently isolated novel extra virgin olive oil polyphenol, oleocanthal, on the human multiple myeloma cell line ARH-77. This natural compound, responsible for the pungency of some of these oils, has a remarkable in vitro activity by inhibiting MIP-1α expression and secretion in MM cells. In addition, is also demonstrated that oleocanthal inhibits MM cells proliferation by inducing the activation of apoptosis mechanisms and by down-regulating ERK1/2 and AKT signal transduction pathways.
"Oleocanthal inhibits proliferation and MIP-1α expression in human multiple myeloma cells." Scotece M, Gómez R, Conde J, Lopez V, Gómez-Reino JJ, Lago F, Smith AB, Gualillo O. Santiago University Clinical Hospital, NEIRID Lab, NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases, Research Area, Laboratory nº 9 Building C, Level -2 Trav. Choupana sn, 15706 Santiago de Compostela, Spain.